Despite claims from some proponents that marijuana use does not cause significant negative effects or withdrawal symptoms, research conducted by cannabis researchers and clinicians has shown otherwise. In fact, studies have found that approximately 47% of regular users of cannabinoids experience symptoms of dependency and withdrawal (Bahji, 2020).
Over the past decade, there has been increased research and public awareness around the issues of drug dependency and withdrawal, but the overall understanding remains fragmented and incomplete. Similar to other addictive substances, cannabinoids can lead to dependency, manifesting in a variety of withdrawal symptoms. However, the severity and individual experiences of withdrawal are highly variable. Some individuals may successfully manage their withdrawal symptoms without medical intervention, while others experience more challenging symptoms that necessitate additional support (Grinspoon, 2020).
Minimizing withdrawal symptoms is a complex and multifaceted process that depends on several variables, including the duration and quantity of cannabinoid use, the quality of the substances consumed, underlying medical conditions, the presence of a supportive environment, and the individual’s motivation to quit. For most heavy users, withdrawal symptoms typically begin within the first 24 hours after cessation, peak between 48 to 72 hours, and generally last for about two to three weeks before subsiding (Addiction Center, 2020).
To alleviate withdrawal symptoms, a combination of remedies is often recommended. These include over-the-counter products designed to act synergistically, addressing both the physical and psychological aspects of withdrawal. Among the most effective of these is S-adenosyl-l-methionine (SAMe), a naturally occurring metabolite that plays a critical role in more than 100 essential physiological methylation reactions within the body. SAMe has been extensively studied for its therapeutic effects in treating depressive disorders, psychiatric conditions, and neurodegenerative diseases (Levine, 2020).
SAMe is particularly beneficial during cannabis withdrawal due to its role in protecting the body from oxidative stress, a condition that commonly arises when the body experiences withdrawal. By restoring homeostasis, SAMe helps maintain normal cellular functions, which is crucial during the withdrawal process. Furthermore, SAMe's involvement in promoting the production of neurotransmitters like serotonin and dopamine makes it an important ally in mitigating the emotional and mental health challenges that often accompany withdrawal (Rose & Melnyk, 2012).
In addition to SAMe, other natural remedies and supplements, such as cannabidiol (CBD) and kratom, are sometimes considered for managing withdrawal symptoms, though their use should be approached cautiously and under professional guidance due to varying levels of research and potential side effects (Levine, 2020).
1. Anees Bahji, MD. Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids A Systematic Review and Meta-analysis. JAMA Network Open. 2020;3(4): e202370.
2. Peter Grinspoon, MD, Contributor. Harvard Health publishing, Harvard Medical School. May 26, 2020.
3. https://www.addictioncenter.com/drugs/marijuana/withdrawal-detox
4. M Taylor Levine. S-adenosyl-l-methionine (SAMe), cannabidiol (CBD), and kratom in psychiatric disorders: Clinical and mechanistic considerations. Brain Behav Immun, 2020 Mar:85:152-161.
5. Rose S,PhD, Melnyk S,MD, PhD. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism Res Treat. 2012:986519.
Management of Cannabis Withdrawal Syndrome
